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Group 1: Placebo Group 2 (Low-dose): Phentermine 7.5mg plus Topiramate 46mg once daily Group 3 (High-dose): Phentermine 15mg plus Topiramate 92mg once daily All participants were monitored for a little over 1 year (56 weeks) and were also provided with some lifestyle counselling that included a LEARN manual (I am not actually sure what this means

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The Quinlan 2022 home-microneedling study in the Journal of Cosmetic Dermatology is the cleanest at-home efficacy signal in the literature: 11 women aged 33 to 61 received twice-daily topical growth factor serum plus twice-weekly microneedling at 0.2mm over three months